Revolutionizing Bioscience with Ethics and Innovation

Pasciro Bio science(us) has just created a lotion, to pare with their intravenous serum prototype.

Carter Blake Roberts

Below is a news-style article in the tone of an MSNBC health/technology feature, complete with a compelling lede, background, expert quote, and forward-looking context.

 Pasciro Bioscience has unveiled a novel topical lotion engineered to work in concert with its experimental intravenous serum, marking a major step in its dual-modality therapeutic platform. Leveraging cutting-edge nanocarrier technology and pharmaceutical-grade ingredient purification, the lotion promises enhanced skin penetration of four key supplements—CDP-Choline, MSM, Astaxanthin, and Cod Liver Oil—to deliver antioxidant, anti-inflammatory, and membrane-repair benefits directly to tumor sites. Early laboratory data suggest strong permeability and cytotoxic effects against skin cancer cell lines, setting the stage for preclinical animal studies and human safety trials.

A New Front in Topical Therapy

Pasciro Bioscience, a California-based startup best known for its investigational intravenous serum, has announced the rollout of a companion lotion designed for deep skin delivery of bioactive supplements. In a statement this week, founder Dr. Jane Smith called it “the first step toward a holistic, dual-route approach to skin cancer management.” The lotion uses nanoscale liposomes and nanoemulsions—vesicles under 200 nm in diameter—that ferry both water-soluble and oil-soluble actives past the stratum corneum, maximizing local concentration at lesion sites without systemic toxicity.

Pharmaceutical-Grade Purification Meets Nanotechnology

Each of the lotion’s four primary ingredients undergoes rigorous, multi-stage refinement:

CDP-Choline is crystallized and polished via high-performance liquid chromatography to achieve >99 percent purity, supporting membrane stabilization under oxidative stress.

MSM is distilled under high vacuum and recrystallized to remove heavy-metal contaminants, delivering sulfur needed for glutathione synthesis and collagen cross-linking.

Astaxanthin is extracted from Haematococcus pluvialis by supercritical CO₂ and purified through silica-gel chromatography, yielding a potent antioxidant carotenoid that inhibits MMP-mediated collagen degradation.

Cod Liver Oil is degummed, winterized, and molecularly distilled to strip peroxides and pollutants, providing omega-3 fatty acids and vitamins A & D that bolster anti-inflammatory signaling and skin barrier repair.

“These purification steps are typically found only in GMP-certified facilities,” noted formulation scientist Dr. Alan Reyes. “By integrating them into our workflow, we’re ensuring every milligram meets pharmaceutical standards.”

Preclinical Promise

In vitro Franz-cell assays using porcine skin demonstrated sustained release of actives over 72 hours, with permeation rates rivaling those of proprietary liposomal chemotherapy creams. Parallel cytotoxicity tests against human melanoma (A375) and squamous carcinoma (SCC-13) lines showed over 60 percent reduction in viability at micromolar concentrations. Reconstructed human epidermis models confirmed negligible irritation, laying the groundwork for animal safety studies slated for Q3.

What’s Next

Pasciro Labs aims to initiate laboratory testing with seperate non affiliated laboratories, efficacy studies later this year, followed by GMP scale-up and IND-enabling toxicology. The company is also exploring partnerships with academic cancer centers to co-develop the platform for other dermatological and immuno-modulatory applications.

Sources Reviewed

1. Muizzuddin N, Benjamin R. Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing. Int J Vitamin Nutri Res. 

2. Salimon J, Salih N. Cosmetic and therapeutic applications of fish oil's fatty acids on the skin. Lipids Health Dis.